| Identification | Back Directory | [Name]
DAT-230 | [CAS]
1504583-00-9 | [Synonyms]
DAT-230
Benzenamine, 2-methoxy-5-[2-(3-methoxy-4,5-dimethylphenyl)-3-thienyl]- | [Molecular Formula]
C20H21NO2S | [MOL File]
1504583-00-9.mol | [Molecular Weight]
339.45 |
| Hazard Information | Back Directory | [Uses]
DAT-230 is a microtubule inhibitor. DAT-230 induces cell apoptosis and results in microtubule de-polymerization and G2/M phase arrest. DAT-230 inhibits cell growth in vitro and in vivo[1][2]. | [References]
[1] Qiao F, et al. DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells. Biol Pharm Bull. 2013;36(2):193-201. DOI:10.1248/bpb.b12-00321
[2] Tang J, et al. Application of an ultra-performance liquid chromatography method with tandem mass spectrometry to pharmacokinetics, tissue distribution and excretion in the study of DAT-230, a novel tubulin-binding agent candidate, in rats. J Pharm Biomed Anal. 2015;110:49-57. DOI:10.1016/j.jpba.2014.09.025 |
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