| Identification | Back Directory | [Name]
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-1,5-dihydro-1-methyl- | [CAS]
1507370-78-6 | [Synonyms]
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-1,5-dihydro-1-methyl- | [Molecular Formula]
C19H22F2N6O3 | [MOL File]
1507370-78-6.mol | [Molecular Weight]
420.41 |
| Hazard Information | Back Directory | [Description]
G-631 is a tankyrase inhibitior and a potential anticancer agent. | [Uses]
G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC50 of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice[1]. | [References]
[1] Zhong Y, et al., Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1. Toxicol Pathol. 2016 Feb;44(2):267-78. DOI:10.1177/0192623315621192 |
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