| Identification | Back Directory | [Name]
7,8-Didehydrocimigenol | [CAS]
150972-72-8 | [Synonyms]
7(8)-Ene-cimigenol
7,8-Didehydrocimigenol
(3beta,15alpha,23R,24S)-16,23:16,24-Diepoxycycloart-7-ene-3,15,25-triol
9,19-Cyclolanost-7-ene-3,15,25-triol, 16,23:16,24-diepoxy-, (3β,15α,16α,23R,24S)-
(3beta,15alpha,16alpha,23R,24S)-16,23:16,24-Diepoxy-9,19-cyclolanost-7-ene-3,15,25-triol | [Molecular Formula]
C30H46O5 | [MOL File]
150972-72-8.mol | [Molecular Weight]
486.68 |
| Hazard Information | Back Directory | [Description]
7,8-Didehydrocimigenol upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. | [Uses]
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1]. | [target]
TNF-α | PPAR | NF-kB | ERK | Akt | IkB | IKK | [References]
[1] Mun L, et al. 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells. Food Chem Toxicol. 2011 Jan;49(1):166-72. DOI:10.1016/j.fct.2010.10.012 |
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