| Identification | Back Directory | [Name]
(20S)-20-(Dimethylamino)-5α-pregnane-3β,4α-diol | [CAS]
15112-49-9 | [Synonyms]
Terminaline
(20S)-20-Dimethylamino-5α-pregnane-3β,4α-diol
(20S)-20-(Dimethylamino)-5α-pregnane-3β,4α-diol
Pregnane-3,4-diol, 20-(dimethylamino)-, (3β,4α,5α,20S)- | [Molecular Formula]
C23H41NO2 | [MOL File]
15112-49-9.mol | [Molecular Weight]
363.58 |
| Hazard Information | Back Directory | [Description]
A steroidal pregnane alkaloid present in Pachysandra terminalis Sieb. et Zucco
The alkaloid is dextrorotatory with [α]D + 29° (1: I-MeOH-CHCI 3). Two
hydroxyl groups are present and the base yields a crystalline O,O-diacetate, m.p.
202-4°C; [α]D + 40° (CHCl3)· | [Uses]
Terminaline is a compound that can be isolated from Sarcococca saligna. Terminaline has immunosuppressive activity and can inhibit the proliferation of T cells and the production of IL-2. In vivo, Terminaline can reduce CCl4-induced liver injury and has a good hepatoprotective effect[1]. | [Definition]
ChEBI: Terminaline is a corticosteroid hormone. | [IC 50]
IL-2 | [References]
Kikuchi, Uyeo, Nishinga., Tetrahedron Lett., 1993 (1965) |
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