| Identification | Back Directory | [Name]
leucettamine A | [CAS]
151124-32-2 | [Synonyms]
leucettamine A
5,8,11,14,17,20-Triacontahexaene-3,28-diol, 2,29-diamino-, (2R,3S,5Z,8Z,11Z,14Z,17Z,20Z,28S,29R)- | [Molecular Formula]
C30H52N2O2 | [MDL Number]
MFCD00918127 | [MOL File]
151124-32-2.mol | [Molecular Weight]
472.75 |
| Hazard Information | Back Directory | [Uses]
Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis[1][2]. | [References]
[1] Sachiko Tsukamoto, et al. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. Microrhaphis. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6319-20. DOI:10.1016/j.bmcl.2008.10.110
[2] Kimberli M Helms, et al. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011 Oct;6(10):1411-6. PMID:22164771 |
|
|