| Identification | Back Directory | [Name]
Propanamide, N-[[4-chloro-3-[2,5-dihydro-5-oxo-1-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]-2,2-dimethyl- | [CAS]
1513852-12-4 | [Synonyms]
GRC-27864
ISC-27864
Zaloglanstat
Zaloglanstat( GRC-27864)
Propanamide, N-[[4-chloro-3-[2,5-dihydro-5-oxo-1-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]-2,2-dimethyl- | [Molecular Formula]
C21H20ClF3N4O2 | [MOL File]
1513852-12-4.mol | [Molecular Weight]
452.86 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (552.05 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.81±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Zaloglanstat (ISC-27864) is a selective and orally active inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 5 nM. Zaloglanstat inhibits PGE2 release of IC50 at 161 nM and 154 nM in whole blood of pigs and dogs, respectively. Zaloglanstat can be used in studies of asthma, osteoarthritis and neurodegenerative diseases[1][2]. | [References]
[1] Di Micco S, Terracciano S, Ruggiero D, Potenza M, Vaccaro MC, Fischer K, Werz O, Bruno I, Bifulco G. Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition. Front Chem. 2021 May 7;9:676631. DOI:10.3389/fchem.2021.676631
[2] Zhang YY, er al. Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance. Pharmacol Res. 2022 Jan;175:105977. DOI:10.1016/j.phrs.2021.105977 |
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