| Identification | Back Directory | [Name]
Penehyclidine HCl (Mixture of IsoMers) | [CAS]
151937-76-7 | [Synonyms]
Penehyclidine HCl
Penehyclidine HCl (Mixture of IsoMers)
2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol,hydrochloride
2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol hydrochloride (1:1) | [Molecular Formula]
C20H30ClNO2 | [MDL Number]
MFCD32709946 | [MOL File]
151937-76-7.mol | [Molecular Weight]
351.92 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, away from moisture | [solubility ]
H2O: 2 mg/mL, clear | [form ]
Liquid | [color ]
Colorless to light yellow | [Water Solubility ]
H2O: 2mg/mL, clear | [InChI]
InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H | [InChIKey]
DDTVVMRZNVIVQM-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1)(C1CCCC1)(O)COC1CN2CCC1CC2.Cl |
| Hazard Information | Back Directory | [Uses]
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1]. | [Biological Activity]
Penehyclidine hydrochloride is a brain penetrant anticholinergic drug th at exhibits both antimuscarinic and antinicotinic activity. Penehyclidine hydrochloride does not induce muscarinic 2 receptor-associated cardiovascular side effects. Penehyclidine hydrochloride is effective in experimental models of heartlung and brain ischemia reperfusion injury. | [in vivo]
Penehyclidine (0.3-3 mg/kg, ip, single dose) exhibits protective activity in rats ALI models[2].
Penehyclidine (1 mg/kg, ip, single dose) enhances the expression of BDNF and phosphorylation of ERK1/2 in the hippocampus, exhibits antidepressant-like effects in mouse CUMS model[4]. | Animal Model: | rats ALI models[2] | | Dosage: | 0.3-3 mg/kg | | Administration: | ip, single dose | | Result: | Alleviated LPS-induced lung injury in rats. |
| Animal Model: | Mouse chronic unpredictable mild stress (CUMS) model[4] | | Dosage: | 1 mg/kg | | Administration: | ip, single dose | | Result: | Reduced the immobility time in the forced swimming test (FST) and tail suspension test (TST). |
| [IC 50]
mAChR1; mAChR3; NF-κB | [storage]
-20°C, away from moisture | [References]
[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Wang X, et al., Penehyclidine hydrochloride alleviates lipopolysaccharide?induced acute respiratory distress syndrome in cells via regulating autophagy?related pathway. Mol Med Rep. 2021 Feb;23(2):100. DOI:10.3892/mmr.2020.11739
[3] Zi C, et al., Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362. DOI:10.1002/cbin.11329
[4] Sun X, et al., A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44(12):2723-2732. DOI:10.1007/s11064-019-02891-5 |
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| Company Name: |
AFINE CHEMICALS LIMITED
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| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
| Company Name: |
Fuxin Pharmaceutical
|
| Telephone: |
+86-021-021-50872116 |
| Website: |
http://www.fuxinpharm.com |
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