| Identification | Back Directory | [Name]
3-Methyl-3-phenylcyclobutanone | [CAS]
151990-53-3 | [Synonyms]
3-Methyl-3-phenylcyclobutanone
Cyclobutanone, 3-methyl-3-phenyl-
3-methyl-3-phenylcyclobutan-1-one
3-methyl-3-phenylCyclobutane-1-one | [Molecular Formula]
C11H12O | [MOL File]
151990-53-3.mol | [Molecular Weight]
160.21 |
| Hazard Information | Back Directory | [Synthesis]
The synthesis of 3-methyl-3-phenylcyclobutanone typically involves constructing a four-membered ring via [2+2] cycloaddition or ring-closing reactions, followed by the introduction of methyl and phenyl substituents. A common strategy is to cyclize precursors such as γ-keto acids or their derivatives; for example, cyclizing (+)-3-methyl-3-phenyladipic acid to form a cyclobutanone ring. Another approach is to first enantioselectively deprotonate the simpler 3-phenylcyclobutanone, followed by methylation of the resulting chiral enol; this method is often used to obtain the enantiomeric pure form of the compound. |
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