15231-41-1

1116-98-9

15231-41-1

The general procedure for the synthesis of tert-butyl 3-aminopropionate from tert-butyl cyanoacetate is as follows: 200 g of tert-butyl cyanoacetate was added to the reactor, followed by the addition of 1 kg of 2% methanol-ammonia aqueous solution and 20 g of Ruannei nickel. The reaction kettle was sealed and replaced three times with nitrogen and then three times with hydrogen. The hydrogen pressure was adjusted to 5 MPa, heated to 55 °C, and the reaction was carried out under stirring for 6 h, during which the hydrogen was continuously replenished. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to about 200 g and diluted with ethyl acetate. After cooling, the pH was adjusted to 3 with ethyl acetate-hydrogen chloride solution, the reaction system was concentrated again and the precipitated solid was dried to give 198 g of the target product tert-butyl 3-aminopropionate.