| Chemical Properties | Back Directory | [Boiling point ]
667.4±55.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.80±0.69(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma. | [Uses]
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma[1][2]. | [in vivo]
BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice[2]. | Animal Model: | NOD/SCID mice[2] | | Dosage: | 60 mg/kg | | Administration: | p.o.; daily for 16 or 12 days | | Result: | Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice. |
| [References]
[1] Zhang P, et al. BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1. Theranostics.?2018 Nov 12;8(21):5890-5902. DOI:10.7150/thno.27667
[2] Hu X, et al. First-in-human phase I study of?BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer.J Hematol Oncol.?2020 Jan 16;13(1):6. DOI:10.1186/s13045-019-0834-2 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|