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152885-49-9

152885-49-9 Structure

152885-49-9 Structure
IdentificationBack Directory
[Name]

Urea, N-[(3R)-5-cyclohexyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methyl-1H-tetrazol-5-ylamino)phenyl]- (9CI)
[CAS]

152885-49-9
[Synonyms]

L736
L-736
L 736
L736380
L-736380
L 736380
Urea, N-[(3R)-5-cyclohexyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methyl-1H-tetrazol-5-ylamino)phenyl]- (9CI)
[Molecular Formula]

C25H29N9O2
[MOL File]

152885-49-9.mol
[Molecular Weight]

487.56
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[pka]

5.27±0.10(Predicted)
Hazard InformationBack Directory
[Description]

L-736380, also known as L-736,380, is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg) and is one of the most potent acidic CCK-B receptor antagonists yet described.
[Uses]

L-736380 is a high affinity CCK-B (cholecystokinin B receptor) receptor antagonist, with IC50 values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID50, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED50, 1.7 mg/kg)[1].
[References]

[1] J L Castro, et al. Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem. 1996 Feb 16;39(4):842-9. DOI:10.1021/jm9506736
152885-49-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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