| Identification | Back Directory | [Name]
PLECONARIL | [CAS]
153168-05-9 | [Synonyms]
Picovir
VP 63843
Rimiducid
WIN 63843
PLECONARIL
Pleconarilis
Pleconaril-d4
PLECONARIL USP/EP/BP
3-[3,5-DiMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
1,2,4-Oxadiazole,3-[3,5-diMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
3-{3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole | [Molecular Formula]
C18H18F3N3O3 | [MDL Number]
MFCD00923611 | [MOL File]
153168-05-9.mol | [Molecular Weight]
381.352 |
| Chemical Properties | Back Directory | [Melting point ]
61-62° | [Boiling point ]
481.2±55.0 °C(Predicted) | [density ]
1.271 | [storage temp. ]
room temp | [solubility ]
DMSO: ≥10mg/mL (warmed) | [form ]
powder | [pka]
-1.33±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3 | [InChIKey]
KQOXLKOJHVFTRN-UHFFFAOYSA-N | [SMILES]
Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Chronic 4 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Picornavirus replication inhibitor. Antiviral. | [General Description]
Pleconaril is a drug, that has antiviral activity. | [Pharmaceutical Applications]
An oxadiazole active against most enteroviruses and rhinoviruses.
It binds to the hydrophobic pocket of the virus capsid
protein VP1, inducing conformational changes that lead to
altered receptor binding and viral uncoating. Concerns over
safety and efficacy have constrained development of the drug. | [Biochem/physiol Actions]
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|