| Identification | Back Directory | [Name]
(2R,3S)-3-PHENYLISOSERINE ETHYLESTER | [CAS]
153433-80-8 | [Synonyms]
TAXOL SIDE CHAIN ETHYL ESTER(SH)
(2R,3S)- Phenylisoserine ethylester
(2R,3S)-3-PHENYLISOSERINE ETHYLESTER
(2R,3S)-N-Benzoyl-3-phenyl Isoserine Eth
BENZYLOXYPHENYLISOSERINE ETHYLESTER,N-(P)
(2R,3S)-ethyl 2,3-diamino-3-phenylpropanoate
(2R,3S)-ethyl3-benzamido-2-hydroxy-3-phenylpropanoate
ethyl (2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate
Ethyl(2R,3S)-3-(benzoylaMino)-2-hydroxybenzenepropanoale
Ethyl (2R,3S)-3-(benzoylamino)-2-hydroxybenzenepropanoate
(αR,βS)-β-(BenzoylaMino)-α-hydroxybenzenepropanoic Acid Ethyl Ester
Benzenepropanoic acid, b-(benzoylamino)-a-hydroxy-, ethyl ester, (aR,bS)-
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, ethyl ester, (αR,βS)- | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C18H19NO4 | [MDL Number]
MFCD11617952 | [MOL File]
153433-80-8.mol | [Molecular Weight]
313.35 |
| Chemical Properties | Back Directory | [Melting point ]
162～163℃ | [Boiling point ]
546.8±50.0 °C(Predicted) | [density ]
1.211±0.06 g/cm3(Predicted) | [solubility ]
Chloroform, Ethyl Acetate, Methanol | [form ]
Solid | [pka]
12.19±0.20(Predicted) | [color ]
White | [CAS DataBase Reference]
153433-80-8 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
(2R,3S)-3-PHENYLISOSERINE ETHYLESTER is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites. (2R,3S)-3-PHENYLISOSERINE ETHYLESTER shows cytotoxic, antiviral and immunomodulatory activity.
| [Synthesis]
The conventional synthesis of ethyl (2R,3S)-3-(benzoylamino)-2-hydroxybenzenepropanoate is mainly made by asymmetric bis-hydroxylation of α,β-unsaturated esters, followed by azide substitution and reduction. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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