| Identification | Back Directory | [Name]
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT | [CAS]
153436-22-7 | [Synonyms]
GAVESTINEL
1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt | [Molecular Formula]
C18H11Cl2N2NaO3 | [MDL Number]
MFCD03700712 | [MOL File]
153436-22-7.mol | [Molecular Weight]
397.187 |
| Chemical Properties | Back Directory | [Melting point ]
>270°C (dec.) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist). | [Biological Activity]
Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo . | [Definition]
ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid. |
| Safety Data | Back Directory | [Safety Profile]
A poison by
intravenous route. When heated to
decomposition it emits toxic vapors of NOx
and Cl-. |
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