| Identification | Back Directory | [Name]
D-Trp(34) neuropeptide Y | [CAS]
153549-84-9 | [Synonyms]
D-Trp(34) neuropeptide Y | [Molecular Formula]
C196H289N55O56 | [MDL Number]
MFCD02098234 | [MOL File]
153549-84-9.mol | [Molecular Weight]
4311.73 |
| Hazard Information | Back Directory | [Uses]
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats[1][2]. | [in vivo]
[D-Trp34]-Neuropeptide Y (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2]. | [IC 50]
NPY Y5 receptor | [References]
[1] E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9. DOI:10.1016/s0196-9781(00)00156-x
[2] Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4. DOI:10.1080/10284150701676222 |
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