| Identification | Back Directory | [Name]
TRIFLUOROACETIC ACID HYDRAZIDE | [CAS]
1538-08-5 | [Synonyms]
uoroacetohydrazide
Trifluoroacetyl Hydrazide
Hydrazine trifluoroacetate
Trifluoroacetohydrazide, tech
2,2,2-Trifluoroacetohydrazide
TRIFLUOROACETIC ACID HYDRAZIDE
1,3-bis(4-nitrophenyl)-2-propanone
2,2,2-trifluoroAcetic acid hydrazide
Acetic acid, 2,2,2-trifluoro-, hydrazide | [Molecular Formula]
C2H3F3N2O | [MDL Number]
MFCD00221440 | [MOL File]
1538-08-5.mol | [Molecular Weight]
128.05 |
| Chemical Properties | Back Directory | [Melting point ]
111 °C | [Boiling point ]
84-86 °C(Press: 14 Torr) | [density ]
1.462±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
solid | [pka]
9.47±0.20(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Trifluoroacetic acid hydrazide is used in chemical synthesis applications. It is used in the preparation of sitagliptin intermediates, pyridazinone derivatives and fluoronitrocarboxylic acid hydrazides, among other organic compounds. | [Synthesis]
Step 2 Preparation of trifluoroacetohydrazide: Ethyl trifluoroacetate (14.2 g, 0.10 mol) and hydrazine hydrate (5.54 g, 0.11 mol) were dissolved in ethanol (25 mL), and heated and refluxed for 6 hours. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the resulting residue was dried under vacuum to obtain trifluoroacetohydrazide (12.3 g, 96% yield), the product was a transparent oil, which was solidified after standing. | [References]
[1] Patent: US6423713, 2002, B1
[2] Patent: US6514977, 2003, B1
[3] Patent: US6979686, 2005, B1. Location in patent: Page/Page column 134
[4] Magnetic Resonance in Chemistry, 1990, vol. 28, p. 331 - 336
[5] Journal of the Indian Chemical Society, 2010, vol. 87, # 5, p. 589 - 593 |
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