| Identification | Back Directory | [Name]
[2H8]-Carbamazepine | [CAS]
1538624-35-9 | [Synonyms]
Carbamazepine-[d8]
[2H8]-Carbamazepine
Carbamazepine-2,3,4,6,7,8,10,11-d8
5H-Dibenz[b,f]azepine-2,3,4,6,7,8,10,11-d8-5-carboxamide
(4,5,6,9,10,13,14,15-2H?)-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide | [Molecular Formula]
C15H12N2O | [MDL Number]
MFCD27665509 | [MOL File]
1538624-35-9.mol | [Molecular Weight]
236.27 |
| Hazard Information | Back Directory | [Uses]
Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2]. | [References]
[1] Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. PMID:6296655
[2] Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. DOI:10.1016/s0920-1211(97)00042-9
[3] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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