| Identification | Back Directory | [Name]
1,3-Benzenedicarboxamide, N3-[(1S,2R)-2-hydroxy-3-[[1-(3-methoxyphenyl)-1-methylethyl]amino]-1-(phenylmethyl)propyl]-5-(1-piperidinyl)-N1,N1-dipropyl- | [CAS]
1539276-38-4 | [Synonyms]
Plm IV inhibitor-2
1,3-Benzenedicarboxamide, N3-[(1S,2R)-2-hydroxy-3-[[1-(3-methoxyphenyl)-1-methylethyl]amino]-1-(phenylmethyl)propyl]-5-(1-piperidinyl)-N1,N1-dipropyl- | [Molecular Formula]
C39H54N4O4 | [MOL File]
1539276-38-4.mol | [Molecular Weight]
642.87 |
| Hazard Information | Back Directory | [Uses]
Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites[1]. | [IC 50]
Plm IV: 24 nM (IC50); Plm II: 70 nM (IC50); Plm I: 0.3 μM (IC50) | [References]
[1] Jaudzems K, et al. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. DOI:10.1021/ml4004952 |
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