| Identification | Back Directory | [Name]
SBFI-26 | [CAS]
1541209-75-9 | [Synonyms]
SBFI-26
SBFI-26 2,4-Diphenyl-cyclobutane-1,3-dicarboxylic acid mono-
naphthalen-1-yl ester monosodium salt | [Molecular Formula]
C28H22O4 | [MOL File]
1541209-75-9.mol | [Molecular Weight]
422.48 |
| Chemical Properties | Back Directory | [Boiling point ]
641.1±55.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/mL
DMSO: Sparingly Soluble: 1-10mg/mL | [pka]
4.07±0.70(Predicted) | [InChIKey]
NVOKBONTLOAJKA-BNZGOVKJNA-N | [SMILES]
C([C@H]1[C@H](C2C=CC=CC=2)[C@H](C(=O)O)[C@H]1C1C=CC=CC=1)(=O)OC1=CC=CC2C=CC=CC1=2 |&1:1,2,9,13,r| |
| Hazard Information | Back Directory | [Description]
SB-FI-26 is an inhibitor of fatty acid binding protein 5 (FABP5) and FABP7 (Kis = 0.93 and 0.4 µM, respectively).1,2 It inhibits arachidonoyl ethanolamide (AEA; Item No. 90050) uptake in wild-type but not FABP5-/- HeLa cells when used at a concentration of 20 µM.1 In vivo, SB-FI-26 (20 mg/kg) reduces nocifensive behavior in phase one of the formalin test and carrageenan-induced thermal hyperalgesia in mice.WARNING This product is not for human or veterinary use. | [References]
[1] WILLIAM T BERGER. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs.[J]. PLoS ONE, 2012: e50968. DOI: 10.1371/journal.pone.0050968
[2] HAO-CHI HSU. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites[J]. Biochemistry Biochemistry, 2017, 56 27: 3454-3462. DOI: 10.1021/acs.biochem.7b00194 |
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