| Identification | Back Directory | [Name]
2-Methyl-1-pentyl-3-(1-naphthoyl)indole | [CAS]
155471-10-6 | [Synonyms]
2-Methyl-1-pentyl-3-(1-naphthoyl)indole
(2-methyl-1-pentylindol-3-yl)-naphthalen-1-ylmethanone
(2-Methyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Methanone, (2-methyl-1-pentyl-1H-indol-3-yl)-1-naphthalenyl- | [Molecular Formula]
C25H25NO | [MOL File]
155471-10-6.mol | [Molecular Weight]
355.47 |
| Hazard Information | Back Directory | [Description]
JWH 007 is a potent cannabinoid (CB) receptor agonist that avidly binds to both CB1 and CB2 (Ki = 9.5 and 2.9 nM, respectively). This compares favorably with the binding of Δ9-THC, which binds CB1 and CB2 with Ki values of 41 and 36 nM, respectively. Similarly, JWH 007 performs comparably to Δ9-THC in mouse studies on spontaneous activity, antinociception, hypothermia, and catalepsy. | [Uses]
Isotope labelled JWH-007 is a novel cannabinoid receptor agonist at both the CB1 and CB2 receptors. | [References]
[1] JOHN W. HUFFMAN ?. Design, Synthesis and Pharmacology of Cannabimimetic Indoles[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4 4: Pages 563-566. DOI: 10.1016/s0960-894x(01)80155-4 |
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