| Identification | Back Directory | [Name]
3,5-dibromo-1-methyl-4-nitro-1H-pyrazole | [CAS]
155600-99-0 | [Synonyms]
3,5-dibromo-1-methyl-4-nitro-1H-pyrazole
1H-Pyrazole, 3,5-dibromo-1-methyl-4-nitro- | [Molecular Formula]
C4H3Br2N3O2 | [MDL Number]
MFCD09972218 | [MOL File]
155600-99-0.mol | [Molecular Weight]
284.89 |
| Chemical Properties | Back Directory | [Melting point ]
153-155° | [Boiling point ]
279.1±35.0 °C(Predicted) | [density ]
2.51±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-5.83±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Example A: Steps for the synthesis of 3,5-dibromo-1-methyl-4-nitro-1H-pyrazole (2):
1. dissolve 3,5-dibromo-4-nitropyrazole (1) (0.934 g, 3.45 mmol) in 5 mL of anhydrous DMF under dry conditions.
2. 100 mL of DMF solution containing 0.16 g of sodium hydride (6.67 mmol) was slowly added dropwise to the above solution over a period of 1 hour.
3. 0.26 mL of iodomethane (CH3I, 3.89 mmol) was added dropwise to the reaction system after gas release ceased.
4. The reaction mixture was stirred at room temperature overnight.
5. Upon completion of the reaction, the solvent was removed by vacuum evaporation.
6. The residue was poured into water and the solid product was separated by filtration. 7.
7. The solid was washed with water and dried under vacuum to give 0.713 g of the target compound 2 in 72.6% yield. | [References]
[1] Patent: US2009/282622, 2009, A1
[2] Patent: US2009/282622, 2009, A1 |
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Cool Pharm, Ltd
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Energy Chemical
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