| Identification | Back Directory | [Name]
H-GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL-OH | [CAS]
156251-01-3 | [Synonyms]
MELAN-A
EAAGIGILTV
MART 1 (26-35)
MART-1 (26-35) (HUMAN)
Melan-A, MART 1 (26-35)
MART-1 (26-35), human (3)
ANTIGEN SK29-AA (26-35) (HUMAN)
ANTIGEN LB39-AA (26-35) (HUMAN)
MELAN-A PROTEIN (26-35) (HUMAN)
GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
H-GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL-OH
MELANOMA ANTIGEN RECOGNIZED BY T-CELLS 1 (26-35) (HUMAN)
L-Valine, L-a-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
L-Valine, L-α-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
MelanoMa Antigen Recognized By T-Cells 1 (26-35) (huMan), Melan-A Protein (26-35) (huMan), Antigen LB39-AA (26-35) (huMan), Antigen SK29-AA (26-35) (huMan)
MART-1 (26-35) (huMan)
MelanoMa Antigen Recognized By T-Cells 1 (26-35) (huMan), Melan-A Protein (26-35) (huMan), Antigen LB39-AA (26-35) (huMan), Antigen SK29-AA (26-35) (huMan) | [Molecular Formula]
C42H74N10O14 | [MDL Number]
MFCD06657941 | [MOL File]
156251-01-3.mol | [Molecular Weight]
943.1 |
| Chemical Properties | Back Directory | [Boiling point ]
1358.4±65.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
lyophilized powder | [pka]
3.32±0.10(Predicted) | [color ]
white | [Water Solubility ]
water, double-distilled: soluble |
| Hazard Information | Back Directory | [Uses]
MART-1 (26-35) (human) is amino acid residue 26 to 35 of MART-1 protein. | [Biological Activity]
Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In additiondeletion of Mart-1 gene leads to parotid metastatic melanoma. | [References]
[1] Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42. DOI:10.1084/jem.180.1.35
[2] Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36. DOI:10.1016/j.jmb.2007.07.025 |
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