| Chemical Properties | Back Directory | [InChI]
InChI=1S/C19H18O5/c1-22-17-10-13(5-6-15(17)21)16-11-14-8-12(4-3-7-20)9-18(23-2)19(14)24-16/h3-6,8-11,20-21H,7H2,1-2H3/b4-3+ | [InChIKey]
ZDQCRQVGMKIBPN-ONEGZZNKSA-N | [SMILES]
C1(O)=CC=C(C2=CC3=CC(/C=C/CO)=CC(OC)=C3O2)C=C1OC |
| Hazard Information | Back Directory | [Uses]
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion[1][2]. | [in vivo]
Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO[1].
| Animal Model: | Eight-week-old male BALB/c mice[1] | | Dosage: | 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg | | Administration: | Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days | | Result: | Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group. |
| [References]
[1] Jin-Kyung Kim, et al. Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Cell Biochem. 2011 Dec;112(12):3816-23. DOI:10.1002/jcb.23312
[2] Yean-Jang Lee, et al. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep. 2006 Oct;16(4):921-7. PMID:16969515 |
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