| Hazard Information | Back Directory | [Description]
L 739749 is a CAAX peptidomimetic; a farnesyl-protein transferase inhibitor. | [Uses]
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro[1]. | [References]
[1] Emanuel P D, et al. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors: Presented in part at the Thirty-Ninth American Society of Hematology Meeting, San Diego, CA, December 5-9, 1997[J]. Blood, The Journal of the American Society of Hematology, 2000, 95(2): 639-645. PMID:10627474 |
|
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|