| Identification | Back Directory | [Name]
PHOSPHORAMIDEMUSTARD | [CAS]
1566-15-0 | [Synonyms]
Ai3-51834
Phosphamide Mustard
Phosphamide Mustard Cyclohexamine Salt
Phosphoramide mustard (cyclohexanamine)
Phosphoramide mustard cyclohexylammonium salt
amino-[bis(2-chloroethyl)amino]phosphinic acid,cyclohexanamine
N,N-Bis(2-chloroethyl)phosphorodiaMidic Acid CyclohexylaMine Salt
Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compound with cyclohexanamine (1:1)
Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compd. with cyclohexanamine(1:1) (9ci) | [Molecular Formula]
C10H24Cl2N3O2P | [MOL File]
1566-15-0.mol | [Molecular Weight]
320.196 |
| Chemical Properties | Back Directory | [Melting point ]
100-103°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Moisture Sensitive |
| Hazard Information | Back Directory | [Uses]
N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580). | [Biological Activity]
Phosphoramide mustard cyclohexanamine induces cytotoxicity by forming cross-linked DNA adducts th at hinder DNA strand separation during replication. This compound destroys rapidly dividing cells and leads to DNA damage. In a study with r at ovarian granulosa cells (SIGCs)it reduced cell viability and increased DNA damage response (DDR) gene expression and protein levels. In animal modelsit exhibited significant anticancer activity by inhibiting tumor growth. These findings highlight the potential of Phosphoramide mustard cyclohexanamine in cancer research | [in vivo]
Phosphoramide mustard cyclohexanamine (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats[2].
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Phosphoramide mustard cyclohexanamine exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg)[2].
| Animal Model: | Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor[2] | | Dosage: | 2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg | | Administration: | Intraperitoneal injection, once daily, for 5 consecutive days | | Result: | Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg. |
| Animal Model: | Rats[2] | | Dosage: | 86.0 mg/kg (Pharmacokinetic Analysis) | | Administration: | Intravenous injection | | Result: | T1/2 (15.1 min). |
| [storage]
Store at -20°C, protect from light, stored under nitrogen |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|