| Identification | Back Directory | [Name]
naftazone | [CAS]
15687-37-3 | [Synonyms]
C05CX02
Etioven
Mediaven
naftazone
Karbinone
Naftazone-d6
naftazone USP/EP/BP
15687-37-3 USP/EP/BP
1,2-naphthoquinone semicarbazone
2-[1-Oxonaphthalen-2(1H)-ylidene]hydrazinecarboxamide
Hydrazinecarboxamide, 2-(1-oxo-2(1H)-naphthalenylidene)- | [EINECS(EC#)]
239-785-1 | [Molecular Formula]
C11H9N3O2 | [MDL Number]
MFCD00867495 | [MOL File]
15687-37-3.mol | [Molecular Weight]
215.21 |
| Hazard Information | Back Directory | [Uses]
2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure. | [Definition]
ChEBI: Naftazone is a member of naphthalenes. | [in vivo]
Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2]. | Animal Model: | Male rats[1] | | Dosage: | 10 and 100 mg/kg | | Administration: | Oral gavage; 10 and 100 mg/kg once per day; for 15 days | | Result: | Significantly reduced glutamate content in cerebro spinal fluid of rats.
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| Animal Model: | Wistar rats[2] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal injection ; 50 mg/kg once daily for 5 days | | Result: | Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet.
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| Company Name: |
LGM Pharma
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| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Shanghai Bank Pharma Limited
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| Tel: |
021-2221346380 021-54220652 17701603001 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList20106/0_EN.htm |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
ISOCHEM
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| Tel: |
609-987-9424 |
| Website: |
www.isochem.fr |
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