| Identification | Back Directory | [Name]
2'-(5''-phosphoribosyl)-5'-adenosine monophosphate | [CAS]
15720-01-1 | [Synonyms]
2'-(5-phosphoribosyl)-5'-AMP
2'-(5''-phosphoribosyl)-5'-adenosine monophosphate
5'-Adenylic acid, 2'-O-(5-O-phosphono-β-D-ribofuranosyl)- | [Molecular Formula]
C15H23N5O14P2 | [MOL File]
15720-01-1.mol | [Molecular Weight]
559.32 |
| Hazard Information | Back Directory | [Uses]
iso-ADP ribose (isoADPr) is a ligand used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2]. | [Definition]
ChEBI: An AMP-sugar in which the 2'-hydroxy group of AMP carries a 5-phospho-beta-D-ribosyl substituent. Monomer unit of poly(ADP-Rib) [poly(adenosine diphosphate ribose)]. | [References]
[1] Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19(2):300-307. DOI:10.1021/acschembio.3c00512
[2] Federico Teloni, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44(3):993-1006. DOI:10.1093/nar/gkv1383 |
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