| Identification | Back Directory | [Name]
L-Valinamide, N,b,b,1-tetramethyl-L-tryptophyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl- | [CAS]
157207-90-4 | [Synonyms]
NSC695242
NSC-695242
NSC 695242
Milnamide B
(-)-Hemiasterlin
L-Valinamide, N,b,b,1-tetramethyl-L-tryptophyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl- | [Molecular Formula]
C30H46N4O4 | [MOL File]
157207-90-4.mol | [Molecular Weight]
526.711 |
| Hazard Information | Back Directory | [Uses]
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. | [IC 50]
Pyrrolobenzodiazepines | [References]
[1] Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):23045-23050. DOI:10.1002/anie.202010090 |
|
|