| Identification | Back Directory | [Name]
MK 996 | [CAS]
157263-00-8 | [Synonyms]
MK 996
L-159282
Benzamide, N-[[4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl][1,1'-biphenyl]-2-yl]sulfonyl]- | [Molecular Formula]
C30H28N4O3S | [MDL Number]
MFCD00922104 | [MOL File]
157263-00-8.mol | [Molecular Weight]
524.63 |
| Hazard Information | Back Directory | [Uses]
L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. | [in vivo]
In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1]. | [storage]
Store at -20°C | [References]
[1] Kivlighn SD, et al. In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996. Am J Hypertens. 1995 Jan;8(1):58-66. DOI:10.1016/0895-7061(94)00169-c |
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