| Identification | Back Directory | [Name]
CP-154,526 | [CAS]
157286-86-7 | [Synonyms]
CP154
CP-154
CP 154
CP-154,526
N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride | [Molecular Formula]
C23H32N4 | [MDL Number]
MFCD00930935 | [MOL File]
157286-86-7.mol | [Molecular Weight]
364.53 |
| Hazard Information | Back Directory | [Uses]
A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | [Biological Activity]
Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | [in vivo]
CP 154526 (1-10 mg/kg; i.p.; once) exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2]. | Animal Model: | Male Sprague Dawley rats[2] | | Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg | | Administration: | i.p.; once | | Result: | Exhibited signs of anxiolytic-like activity.
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| Company Name: |
LETOPHARM LIMITED
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| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
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