| Identification | Back Directory | [Name]
guluronic acid | [CAS]
15769-56-9 | [Synonyms]
guluronic acid
Einecs 239-860-9 | [EINECS(EC#)]
239-860-9 | [Molecular Formula]
C6H10O7 | [MDL Number]
MFCD30533975 | [MOL File]
15769-56-9.mol | [Molecular Weight]
194.139 |
| Chemical Properties | Back Directory | [Boiling point ]
553.434±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.748±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.65 | [color ]
White to off-white | [InChI]
InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3-,4+,5-/m0/s1 | [InChIKey]
IAJILQKETJEXLJ-KLVWXMOXSA-N | [SMILES]
O=C[C@@H]([C@@H]([C@H]([C@@H](C(O)=O)O)O)O)O |
| Questions and Answers (Q&A) | Back Directory | [Description]
Glucuronic acid is a sugar acid derived from glucose, with its sixth carbon atom oxidized to a carboxylic acid. In living beings, this primary oxidation occurs with UDP-α-D-glucose (UDPG), not with the free sugar.
Glucuronic acid, like its precursor glucose, can exist as a linear (carboxo-)aldohexose (<1%), or as a cyclic hemiacetal (furanose or pyranose). Aldohexoses such as D-glucose are capable of forming two furanose forms (α and β) and two pyranose forms (α and β). By the Fischer convention, glucuronic acid has two stereoisomers (enantiomers), D- and L-glucuronic acid, depending on its configuration at C-5. Most physiological sugars are of the D-configuration. Due to ring closure, cyclic sugars have another asymmetric carbon atom (C-1), resulting in two more stereoisomers, named anomers. Depending on the configuration at C-1, there are two anomers of glucuronic acid, α- and β-form. In β-D-glucuronic acid the C-1 hydroxy group is on the same side of the pyranose ring as the carboxyl group. In the free sugar acid, the β-form is prevalent (~64%), whereas in the organism, the α-form UDP-α-D-glucuronic acid (UDPGA) predominates.
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| Hazard Information | Back Directory | [Uses]
Guluronic acid (G2013), one of the organic building blocks of hyaluronic acid, is a nonsteroidal anti-inflammatory agent has favorable anti-inflammatory effect[1][2]. | [References]
[1] Amaniampong PN, et al. Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound. Sci Rep. 2017;7:40650. Published 2017 Jan 13. DOI:10.1038/srep40650
[2] Nazeri S, et al. The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial. Pharmacol Rep. 2019;71(3):393-398. DOI:10.1016/j.pharep.2019.02.002 |
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| Company Name: |
Wuhan Topule
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+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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cjbscvictory
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13348960310 13348960310 |
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www.weikeqi-biotech.com/ |
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