| Identification | Back Directory | [Name]
Tropodifene | [CAS]
15790-02-0 | [Synonyms]
Tropaphen
Tropodifene
Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester | [Molecular Formula]
C25H29NO4 | [MDL Number]
MFCD00869003 | [MOL File]
15790-02-0.mol | [Molecular Weight]
407.5 |
| Chemical Properties | Back Directory | [Boiling point ]
508.5±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.99±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor. | [in vivo]
Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits[1]. | [References]
[1] Mashkovskii MD, et al. The action of tropaphen on the peripheral vessels. Pharmacology. 1964. 58. 69-71. |
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