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1579278-89-9

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1579278-89-9 Structure

1579278-89-9 Structure

Identification	Back Directory
[Name] QL47R
[CAS] 1579278-89-9
[Synonyms] QL47R
[Molecular Formula] C27H23N5O2
[MOL File] 1579278-89-9.mol
[Molecular Weight] 449.5

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[Boiling point ] 781.686±60.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.361±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 7.261±0.20(predicted)
[color ] Off-white to light yellow

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[Uses] QL47R is an approximately isosteric analogue of QL47 (HY-80003). QL47R dose not inhibit the biochemical kinase activity of BTK at concentrations below 10 μM. QL47R dose not display antiproliferative activity on B-Cell Lymphoma Cell Lines at concentrations of less than 10 μM[1].
[References] [1] Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014 May 16;9(5):1086-91. DOI:10.1021/cb4008524

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