| Identification | Back Directory | [Name]
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one | [CAS]
158299-05-9 | [Synonyms]
BPSBC
BR-Comp
-cyclohexan]-4-one
3-(2-Bromo-1-oxoprop
Meropenem Intermediate
3-(2-bromopropanoyl)-3,4-dihydrospiro[1,3-benzoxazine-2,1'
3-isobutyrylspiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one
3-(2-bromo-1-oxopropyl)-4-spiro[1,3-benzoxazine-2,1'-cyclohexane]one
3-(2-broMopropionyl)spiro[2H-1,3-benzoxazine-2,1'-cyclohexane]-4(3H)-one
3-(2-BroMopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one
3-(2-BROMO-1-OXOPROPYL)-SPIRO[2H-1,3-BENZOXAZINE-2,1'-CYCLOHEXAN]-4(3H)-ONE
Spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one, 3-(2-bromo-1-oxopropyl)-
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-ketone
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one (BPSBC)
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one USP/EP/BP
3-(2-BroMo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one (M2)
broMine propionyl snails benzoxazin cyclohexane-3-(2-broMine-generation-1-oxo-propyl)-Lo [2H-1,3-benzoxazine -2,1'-cyclohexane]-4(3H)-ketone | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C16H18BrNO3 | [MDL Number]
MFCD08458252 | [MOL File]
158299-05-9.mol | [Molecular Weight]
352.22 |
| Chemical Properties | Back Directory | [Melting point ]
74-76 °C | [Boiling point ]
485.0±45.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [Fp ]
247.1°C | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
-2.33±0.20(Predicted) | [InChI]
InChI=1S/C16H18BrNO3/c1-11(17)14(19)18-15(20)12-7-3-4-8-13(12)21-16(18)9-5-2-6-10-16/h3-4,7-8,11H,2,5-6,9-10H2,1H3 | [InChIKey]
APCHXTHKSJHPPE-UHFFFAOYSA-N | [SMILES]
O1C2=CC=CC=C2C(=O)N(C(=O)C(Br)C)C21CCCCC2 | [CAS DataBase Reference]
158299-05-9 |
| Hazard Information | Back Directory | [Chemical Properties]
25KG | [Uses]
3-(2-Bromo-1-oxopropyl)-spiro[2h-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one is an intermediate of meropenem, and meropenem is a carbapenem antibiotic, which is suitable for the treatment of meningitis. | [Application]
A useful research chemical compound. | [Synthesis]
Comparative Example 1: 1.4,80 g of spiro[benzo[e][1,3]oxazine-2,1'-cyclohexyl]-4(3H)-one, 127 g of 2-bromopropionyl bromide, and 40 g of pyridine (molar ratio 1:1.6:1) were dissolved in chlorobenzene (mass ratio 1:4.4). The mixture was placed in a four-necked flask under nitrogen protection and reacted at 50 °C for 8 hours. After completion of the reaction, the mixture was washed three times with 200 g of water, three times with 200 g of 10% potassium hydroxide solution and three times with 200 g of water, in that order. The organic phases were combined and concentrated under reduced pressure to remove the solvent to obtain a colorless liquid. To this liquid was added 80 g of ethanol (mass ratio 1:1), cooled to -5 °C, stirred for 2 h, filtered and dried to give 109 g of 3-(2-bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1 '-cyclohexyl]-4(3H)-one. The molar yield was 84.5% and the purity was 97.9%. | [storage]
Store the container tightly closed in a dry, cool and well-ventilated
place. Store apart from foodstuff containers or incompatible materials. | [References]
[1] Journal of Organic Chemistry, 1995, vol. 60, # 5, p. 1096 - 1097
[2] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 23, p. 2851 - 2856
[3] Journal of Organic Chemistry, 1997, vol. 62, # 9, p. 2877 - 2884
[4] Patent: CN106432122, 2017, A. Location in patent: Paragraph 0070-0072
[5] Patent: US5442055, 1995, A |
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