| Identification | Back Directory | [Name]
Incyclinide | [CAS]
15866-90-7 | [Synonyms]
CMT 3
COL 3
Metastat
NSC 683551
Incyclinide
INCYCLINIDE (CMT-3, COL-3)
2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)- | [Molecular Formula]
C19H17NO7 | [MDL Number]
MFCD09970644 | [MOL File]
15866-90-7.mol | [Molecular Weight]
371.34 |
| Chemical Properties | Back Directory | [Melting point ]
228-231 °C | [Boiling point ]
752.8±60.0 °C(Predicted) | [density ]
1.70±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);269.29(Max Conc. mM) | [form ]
A solid | [pka]
4.50±1.00(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Treatment of
acne, rosacea, and acute respiratory distress syndrome. | [Brand name]
Metastat (CollaGenex). | [in vivo]
Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix[3]. |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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