| Identification | Back Directory | [Name]
Dihydrexidine Hydrochloride | [CAS]
158704-02-0 | [Synonyms]
(+)-DAR-0100 (hydrochloride)
(+)-DAR-0100 (hydrochloride)
(+)-Dihydrexidine hydrochloride | [Molecular Formula]
C17H18ClNO2 | [MDL Number]
MFCD30747888 | [MOL File]
158704-02-0.mol | [Molecular Weight]
303.79 |
| Chemical Properties | Back Directory | [Melting point ]
>122 °C (decomp)(Solv: ethyl acetate (141-78-6); isopropanol (67-63-0)) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 10 mM in water and to 50 mM in DMSO | [form ]
Powder |
| Hazard Information | Back Directory | [Description]
A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo. | [Uses]
(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. | [in vivo]
To examine the functional state of striatal neurons in response to D1 receptor activation, AC5+/+ and AC5-/- mice are injected with the D1 agonist (+)-Dihydrexidine (30 mg/kg, i.p.) and obtained the dorso-lateral striatum and NAc, separately, 45 min later for RT-PCR analysis. These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes, c-fos, egr-1, and junB, in the NAc is markedly enhanced in AC5-/- mice compared with that in AC5+/+ mice, while the induction in the dorso-lateral striatum is suppressed in AC5-/- mice[3]. | [storage]
Store at -20°C | [References]
[1] Lewis MM, et al. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitizationdissociates from both receptor occupancy and functional potency. J Pharmacol Exp Ther. 1998 Jul;286(1):345-53. PMID:9655879
[2] Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. PMID:1352553
[3] Kim KS, et al. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. J Neurochem. 2008 Oct;107(1):105-15. DOI:10.1111/j.1471-4159.2008.05592.x |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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