158966-62-2

934537-35-6

158966-62-2

7V-(2-chloro-6-methoxyphenyl)-2,2-dimethylpropanamide (3.89 g, 16.1 mmol) was used as a raw material, which was mixed with acetic acid (40 mL) and concentrated aqueous hydrochloric acid (20 mL). The reaction mixture was heated at 75 °C for 72 hours. After the reaction was completed, it was cooled to room temperature and neutralized with concentrated aqueous ammonia solution. The target product 2-chloro-6-methoxyaniline was extracted with ethyl acetate, the organic phases were combined and concentrated. The crude product was purified by column chromatography followed by reduced pressure distillation (boiling point: 140 °C, 0.25 mbar) to give 2-chloro-6-methoxyaniline (2.24 g, 88% yield).