| Identification | Back Directory | [Name]
1H,3H-Furo[3',4':4,5]cyclohept[1,2-d]isobenzofuran-3,10(8H)-dione, 8-(3-furanyl)-5,6-dihydro-5-hydroxy-7-methyl-, (5R,8R,12aS)- | [CAS]
158994-32-2 | [Synonyms]
Salviandulin E
1H,3H-Furo[3',4':4,5]cyclohept[1,2-d]isobenzofuran-3,10(8H)-dione, 8-(3-furanyl)-5,6-dihydro-5-hydroxy-7-methyl-, (5R,8R,12aS)- | [Molecular Formula]
C20H16O6 | [MOL File]
158994-32-2.mol | [Molecular Weight]
352.34 |
| Hazard Information | Back Directory | [Uses]
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 μg/mL[1][2]. | [IC 50]
Trypanosoma | [References]
[1] Narukawa Y, et al. A novel diterpenoid with a rearranged neoclerodane skeleton from Salvia leucantha CAV. J Nat Med. 2006 Jul;60(3):206-209. DOI:10.1007/s11418-006-0037-3
[2] Aoyagi Y, et al. Semisynthesis of salviandulin E analogues and their antitrypanosomal activity. Bioorg Med Chem Lett. 2014 Jan 15;24(2):442-6. DOI:10.1016/j.bmcl.2013.12.052 |
|
|