| Identification | Back Directory | [Name]
BIBP 3226 | [CAS]
159013-54-4 | [Synonyms]
BIBP 3226 trifluoroa
BIBP 3226 trifluoroacetate
BIBP3226 trifluoroacetate salt Diphenylacetyl-D-Arg-4-hydroxybenzylamide trifluoroacetate salt
(2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide
Benzeneacetamide, N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-
N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamidetrifluoroacetate | [Molecular Formula]
C27H31N5O3 | [MDL Number]
MFCD00938562 | [MOL File]
159013-54-4.mol | [Molecular Weight]
473.57 |
| Chemical Properties | Back Directory | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: 1 mg/mL | [form ]
A solid | [pka]
9.71±0.15(Predicted) | [Water Solubility ]
H2O: 1mg/mL | [InChIKey]
KUWBXRGRMQZCSS-HSZRJFAPSA-N | [SMILES]
NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c2ccccc2)C(=O)NCc3ccc(O)cc3 |
| Hazard Information | Back Directory | [Uses]
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2]. | [Biological Activity]
Mixed non-peptide neuropeptide Y Y 1 (NPY Y 1 ) and neuropeptide FF (NPFF) receptor antagonist (K i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y 1 , hNPFF 2 , rNPFF, rNPY Y 2 , rNPY Y 4 and rNPY Y 5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration. | [Biochem/physiol Actions]
Selective non-peptide neuropeptide Y1 (NPY1) receptor antagonist. | [in vivo]
BIBP3226 (0.5, 5 μg; i.c.v.; male Wistar rats) induces an anxiogenic-like effect at the higher dose[1]. | [References]
[1] Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. DOI:10.1038/sj.bjp.0704049 |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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