| Identification | Back Directory | [Name]
MSN-125 | [CAS]
1592908-16-1 | [Synonyms]
MSN-125
Benzenepropanamide, N-[(2R,3S)-2-(aminomethyl)-2,3-dihydro-6-[(2-methoxyethoxy)methoxy]-3-benzofuranyl]-α-(benzoylamino)-N-[(4-bromophenyl)methyl]-, (αS)- | [Molecular Formula]
C36H38BrN3O6 | [MDL Number]
MFCD34187343 | [MOL File]
1592908-16-1.mol | [Molecular Weight]
688.61 |
| Chemical Properties | Back Directory | [Boiling point ]
860.2±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
13.00±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1]. | [IC 50]
Bax; Bak | [References]
[1] Niu X, et al. A?Small-Molecule?Inhibitor?of?Bax?and?Bak?Oligomerization?Prevents?Genotoxic?Cell?Death?and?Promotes?Neuroprotection. Cell?Chem Biol.?2017 Apr 20;24(4):493-506.e5. DOI:10.1016/j.chembiol.2017.03.011 |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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