| Identification | Back Directory | [Name]
WSP-5 | [CAS]
1593024-78-2 | [Synonyms]
WSP-5
DSMMZTASSIAQPQ-UHFFFAOYSA-N
Benzoic acid, 2-(2-pyridinyldithio)-, 1,1'-(3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl) ester | [Molecular Formula]
C44H26N2O7S4 | [MOL File]
1593024-78-2.mol | [Molecular Weight]
822.94 |
| Chemical Properties | Back Directory | [density ]
1.57±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml | [form ]
A crystalline solid | [pka]
1.69±0.19(Predicted) | [color ]
White to off-white | [InChIKey]
DSMMZTASSIAQPQ-UHFFFAOYSA-N | [SMILES]
O=C1C2=CC=CC=C2C2(C3=CC=C(OC(C4C=CC=CC=4SSC4N=CC=CC=4)=O)C=C3OC3=CC(OC(C4C=CC=CC=4SSC4N=CC=CC=4)=O)=CC=C23)O1 |
| Hazard Information | Back Directory | [Description]
Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a turn-on fluorescent probe for hydrogen sulfide (H2S). Upon reaction with H2S, WSP-5 releases a fluorophore that displays excitation/emission maxima of 502/525 nm, respectively. WSP-5 exhibits a faster turn-on rate and a more sensitive detection limit toward H2S than WSP-1 . | [Uses]
WSP-5 is a fluorescent probe for fast detection of H2S in biological samples and cells. WSP-5 selectively and rapidly reacts with H2S and exhibits fluorescence through a reaction-based fluorescent turn-on strategy. | [storage]
Store at -20°C, protect from light | [References]
[1] BO PENG. Fluorescent Probes Based on Nucleophilic Substitution–Cyclization for Hydrogen Sulfide Detection and Bioimaging[J]. Chemistry - A European Journal, 2013, 20 4: 1010-1016. DOI: 10.1002/chem.201303757
[2] YINGZHU ZHOU. Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection[J]. Chemistry - An Asian Journal, 2022, 17 5. DOI: 10.1002/asia.202101399
[3] HALINA JURKOWSKA. New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor[J]. Amino Acids, 2018, 50 6: 699-709. DOI: 10.1007/s00726-018-2546-2
[4] CRISTIANE J. DA SILVA . NO, hydrogen sulfide does not come first during tomato response to high salinity[J]. Nitric oxide?: biology and chemistry, 2018, 76: Pages 164-173. DOI: 10.1016/j.niox.2017.09.008 |
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Rhawn Reagent
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Merck KGaA
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