| Identification | Back Directory | [Name]
Ro 25-1553 | [CAS]
159427-08-4 | [Synonyms]
Ro 25-1553
L-Threoninamide, N-acetyl-L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-glutamyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-norleucyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-α-aspartyl-L-leucyl-L-...
L-Threoninamide, N-acetyl-L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-glutamyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-norleucyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-α-aspartyl-L-leucyl-L-lysyl-L-lysylglycylglycyl-, (25→21)-lactam | [Molecular Formula]
C160H258N46O46 | [MOL File]
159427-08-4.mol | [Molecular Weight]
3562.05 |
| Hazard Information | Back Directory | [Uses]
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model[1]. | [References]
[1] K?llstr?m BL, et al., Bronchodilating properties of the VIP receptor agonist Ro 25-1553 compared to those of formoterol on the guinea-pig isolated trachea. Eur J Pharmacol. 2001 Nov 2;430(2-3):335-40. DOI:10.1016/s0014-2999(01)01299-7 |
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