| Identification | Back Directory | [Name]
7-Chloro-[1,8]naphthyridin-2-ol | [CAS]
15944-34-0 | [Synonyms]
7-Chloro-[1,8]naphthyridin-2-ol
7-Chloro-1H-[1,8]naphthyridin-2-one
1,8-Naphthyridin-2(1H)-one, 7-chloro- | [Molecular Formula]
C8H5ClN2O | [MDL Number]
MFCD17215762 | [MOL File]
15944-34-0.mol | [Molecular Weight]
180.59 |
| Chemical Properties | Back Directory | [Melting point ]
255-257℃ | [Boiling point ]
379.4±44.0 °C(Predicted) | [density ]
1.50 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
1.74±0.40(Predicted) | [Appearance]
Brown to reddish brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Tert-butyl 3-[6-chloro-2-(2,2-dimethylpropanamido)pyridin-3-yl]-3-hydroxypropanoate (4 g, 11 mmol) was used as a raw material, which was dissolved in a mixed solution of 1 M HCl/dioxane (1:1, 50 mL) and reacted overnight. After completion of the reaction, ice water was added to the mixture and the precipitated solid was collected by filtration and dried to afford 7-chloro-1,8-diazanaphthalen-2-ol (1.7 g, 9.4 mmol, 86% yield). The obtained product could be used in the subsequent reaction without further purification.LC-MS analysis showed the (M-H)-peak was 181.1. | [References]
[1] Journal of Organic Chemistry, 1990, vol. 55, # 15, p. 4744 - 4750
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 94 |
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| Company Name: |
Andxi Pharm Co., Ltd.
|
| Tel: |
19951207836 |
| Website: |
www.chemicalbook.com/showsupplierproductslist1180646/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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