| Identification | Back Directory | [Name]
Di-t-Butyl Bromomalonate | [CAS]
15960-79-9 | [Synonyms]
Di-t-Butyl Bromomalonate
di-tert-butyl 2-bromomalonate
1,3-di-tert-butyl 2-bromopropanedioate
1,3-Bis(1,1-dimethylethyl) 2-bromopropanedioate
Propanedioic acid, 2-bromo-, 1,3-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C11H19BrO4 | [MDL Number]
MFCD17013228 | [MOL File]
15960-79-9.mol | [Molecular Weight]
295.17 |
| Hazard Information | Back Directory | [Synthesis]
The Preparative Method of Di-t-Butyl Bromomalonate: by bromination of Malonic Acid with bromine in diethyl ether at rt followed by sulfuric acid catalyzed esterification with Isobutene in diethyl ether at rt; by bromination of di-t-butyl malonate with bromine and Calcium Carbonate in chloroform at rt followed by reflux; by lithiation of di-t-butyl malonate with n-Butyllithium in THF at -78 °C followed by addition of bromine and allowing reaction to warm to rt;10 by lithiation of di-t-butyl malonate with n-butyllithium in THF at -78 °C, addition of Chlorotrimethylsilane, warming to rt, and treatment of the resulting trimethylsilyl ketene acetal solution with bromine in carbon tetrachloride.
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