| Identification | Back Directory | [Name]
N-[(Phenylmethoxy)carbonyl]glycyl-L-prolyl-N-[(1S)-1-formyl-3-methylbutyl]-L-phenylalaninamide | [CAS]
159659-05-9 | [Synonyms]
N-[(Phenylmethoxy)carbonyl]glycyl-L-prolyl-N-[(1S)-1-formyl-3-methylbutyl]-L-phenylalaninamide | [Molecular Formula]
C30H38N4O6 | [MOL File]
159659-05-9.mol | [Molecular Weight]
550.65 |
| Chemical Properties | Back Directory | [Boiling point ]
847.2±65.0 °C(Predicted) | [density ]
1.212±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
11.34±0.46(Predicted) | [Sequence]
Z-Gly-Pro-Phe-Leu-CHO |
| Hazard Information | Back Directory | [Uses]
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 μM for branched chain amino acid preferring, 2.3 μM for small neutral amino acid preferring, and 40.5 μM for chymotrypsin-like activities; IC50 = 3.1 μM for peptidyl-glutamyl peptide hydrolyzing activity)[1]. | [References]
[1] M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53. DOI:10.1021/bi970666e |
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