| Identification | Back Directory | [Name]
Linetastine | [CAS]
159776-68-8 | [Synonyms]
Linetastine
Unii-7U248Z56la
Linetastine [inn]
[4-[(1E,3E)-5-[2-(4-benzhydryloxypiperidin-1-yl)ethylamino]-5-oxopenta-1,3-dienyl]-2-methoxyphenyl] ethyl carbonate
Carbonic acid, 4-[(1E,3E)-5-[[2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl]amino]-5-oxo-1,3-pentadien-1-yl]-2-methoxyphenyl ethyl ester | [Molecular Formula]
C35H40N2O6 | [MOL File]
159776-68-8.mol | [Molecular Weight]
584.7 |
| Hazard Information | Back Directory | [Uses]
Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes[1]. | [in vivo]
Linetastine inhibits histamine-induced bronchoconstriction dose-dependently at 1-10 mg/kg (p.o.) in guinea-pigs, and the effect lasts for more than 24 h[1]. | [IC 50]
5-Lipoxygenase; Histamine Receptor | [References]
[1] Shizawa T, et al. 5-Lipoxygenase inhibitory and antihistamine activities of linetastine. Arzneimittelforschung. 1996 Nov;46(11):1072-6. PMID:8955867 |
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