| Identification | Back Directory | [Name]
cis-Diamminediiodoplatinum | [CAS]
15978-93-5 | [Synonyms]
Pt(NH3)2I2
diamminediiodoplatinum
cis-diamminediiodoplatinum
cis-Diammineplatinous iodide
Diiodide diamine and platinum
cis-DiiododiaMMineplatinuM(II)
cis-Diamminediiodoplatinum (II)
rans-di-iododiammineplatinum(II)
trans-di-iododiammineplatinum(II)
Platinum(2+) iodide ammoniate (1:2:2) | [EINECS(EC#)]
240-115-5 | [Molecular Formula]
H6I2N2Pt | [MDL Number]
MFCD00799631 | [MOL File]
15978-93-5.mol | [Molecular Weight]
482.95 |
| Hazard Information | Back Directory | [Uses]
cis-Diiododiammineplatinum(II) is a diiodo analog of cis-platin. cis-Diiododiammineplatinum(II) exhibits similar DNA binding modes as cis-platin by greater DNA reactivities towards tumor cell lines. | [Pharmaceutical Applications]
cis-Diamminediiodoplatinum was first reported in 1844 and named Peyrone's chloride after its inventor. Recently, this compound has been of particular interest because it has been found to have anti-cancer activity. | [Synthesis]
A process for preparing a cis-diamminediiodoplatinum(II) complex of high
purity and in high yield from potassium tetraiodoplatinum(II) by a
method comprising adding an aqueous solution of ammonium hydroxide to an
aqueous dispersion of potassium tetraiodoplatinum(II), said tetraiodo
compound having the formula K2 PtI4,
under a controlled gradually rising temperature profile while
controlling the ammonium hydroxide addition so that the pH does not
exceed about 7.5. |
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