| Identification | Back Directory | [Name]
ent-8-iso Prostaglandin F2α | [CAS]
159812-83-6 | [Synonyms]
ent-8-iso Prostaglandin F2α
PXGPLTODNUVGFL-VCKDCIDJSA-N
ent-8-iso Prostaglandin F2.alpha. | [Molecular Formula]
C20H34O5 | [MOL File]
159812-83-6.mol | [Molecular Weight]
354.481 |
| Chemical Properties | Back Directory | [Boiling point ]
531.0±50.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but also have been found to have a potent biological activity. ent-8-iso Prostaglandin F2α (ent-8-iso PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.1 | [Uses]
ent-8-iso Prostaglandin F2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively[1]. | [References]
1. Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al. Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature Free Radic. Biol. Med. 36(2),163-172(2004). |
|
|