| Identification | Back Directory | [Name]
L-BMAA HYDROCHLORIDE | [CAS]
16012-55-8 | [Synonyms]
L-BMAA.HCL
β-Methylamino-L-alanine Hydrochloride
β-N-methylamino-L-alanine hydrochloride
3-(Methylamino)-L-alanine monohydrochloride
(S)-2-AMINO-3-(METHYLAMINO)PROPANOIC ACID HCL
L-Alanine, 3-(methylamino)-, hydrochloride (1:1)
L-2-aMino-3(MethylaMino)propanoic acid hydrochloride
s(+)-2-amino-3-(methylamino)propionic acid hydrochloride
(2S)-2-amino-3-(methylamino)propanoic acid hydrochloride
H-Dap(Me)-OH
(S)-2-Amino-3-(methylamino)propanoic acid hydrochloride | [Molecular Formula]
C4H10N2O2HCl | [MDL Number]
MFCD00055227 | [MOL File]
16012-55-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
>147°C (dec.) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble (solutions may be stored for several days at 4°C) | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]20/D +35°, c = 1.15 in 5 M HCl(lit.) | [Water Solubility ]
Soluble to 60 mM in water | [Stability:]
Hygroscopic | [InChI]
1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1 | [InChIKey]
VDXYGASOGLSIDM-DFWYDOINSA-N | [SMILES]
Cl.CNC[C@H](N)C(O)=O |
| Hazard Information | Back Directory | [Uses]
L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium?to treat the cells of?Phaeodactylum tricornutum and?Thalassiosira weissflogii?to study its effect on them. | [General Description]
L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin. | [Biochem/physiol Actions]
L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease. | [in vivo]
β-N-methylamino-L-alanine (460 mg/kg, s.c., daily, 2 weeks) hydrochloride inhibits melatonin synthesis in a Wistar rat model[4].
β-N-methylamino-L-alanine (BMAA-HCl, 400 mg kg, s.c.) hydrochloride induces developmental neurotoxicity in a rat model[5].
β-N-methylamino-L-alanine (100-350 mg/kg, i.p., 5 consecutive days) hydrochloride causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS) in male rats[6].
β-N-methylamino-L-alanine (5-10 nmol, intravitreal injections) hydrochloride induces in vivo retinal cell death in mice[8].
β-N-methylamino-L-alanine (250 mg/kg, i.p., 5 consecutive days) hydrochloride produces oxidative damage in liver and kidney of rats, with the significant increase of lipid peroxidation and high catalase activity[12].
β-N-methylamino-L-alanine (40-460 mg/kg, s.c., 2 days) hydrochloride perturbs the intermediary metabolism in neonatal rats, with impairments in learning and memory function[13].
| [IC 50]
mGluR3 | [storage]
Store at -20°C |
|
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