| Identification | Back Directory | [Name]
HPV16 E7(86-93) | [CAS]
160212-93-1 | [Synonyms]
HPV16 E7(86-93)
Thr-Leu-Gly-Ile-Val-Cys-Pro-Ile | [Molecular Formula]
C37H66N8O10S | [MDL Number]
MFCD32068004 | [MOL File]
160212-93-1.mol | [Molecular Weight]
815.03 |
| Chemical Properties | Back Directory | [Boiling point ]
1168.2±65.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [pka]
3.72±0.22(Predicted) | [Sequence]
Thr-Leu-Gly-Ile-Val-Cys-Pro-Ile |
| Hazard Information | Back Directory | [Uses]
HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas[1][2]. | [in vivo]
HPV16 E7 (86-93) peptide in IVS culture has specific T cell expansion. The HPV16 E7 (86-93) specific T cells produced does not recognize naturally HPV16 E7 expressing cell line CaSki. HPV16 E7 (86-93) peptides also has similar observations in transgenic mice. The HPV16 E7 (86-93) peptide is able to induce cytotoxic T lymphocyte (CTL) responses if loaded on the antigen presenting HLA class I molecules, but that the peptide appears not to be processed or presented by HPV16 infected cells[1]. | [References]
[1] Cheng WF, et al. Induction of human papillomavirus type 16-specific immunologic responses in a normal and an human papillomavirus-infected populations. Immunology. 2005 May;115(1):136-49. DOI:10.1111/j.1365-2567.2005.02126.x
[2] Hoffmann TK, et al. T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx. Int J Cancer. 2006 Apr 15;118(8):1984-91. DOI:10.1002/ijc.21565 |
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